If republicans were smart they'd move South Carolina out of the early primary season. It has produced two of the worst examples of winning gutter primary politics in recent memory - Bush's race baiting of McCain in 2000, and Gingrich's blatantly bigoted campaign/win this year. I don't believe SC is the cause of the problem, but it's ugliness is often the worst symptom of the problem; on the democrat side let's not forget Bill Clinton's Jesse Jackson comment in 2008. It's pretty obvious the republicans will hold the south for awhile, they don't need it to determine who their nominee is. Let's not forget Iowa loves religious right loons (Huckabee 08, Santorum '12), opening the possibility that a joke character can win there and then win in SC.
Removing it could also significantly decrease the shelf life of clown candidates like Gingrich, Bachman, Cain, etc who "forced" Romney to move far right just to win the nomination. Iowa, NH, Florida, Nevada, and Colorado should be the fist states (note: that's how it would look if SC was simply removed from the current primary schedule)