THE BORE

General => The Superdeep Borehole => Topic started by: TVC15 on July 24, 2008, 02:07:13 PM

Title: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:07:13 PM: I did some quick math the other day but me am can not very good with numbers. As of right now, I'm taking about 4800 to 6000mg a day, depending on how bad the pain is. I've been trying to cut down the doses, but when I do, I go to pain mouthgout city.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: FlameOfCallandor on July 24, 2008, 02:09:40 PM: Be sure to tell us the magic amount after you find out.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Human Snorenado on July 24, 2008, 02:10:38 PM: WTF are you taking so much ibuprofen for anyway? Get good pain killers if you've got pain.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: FlameOfCallandor on July 24, 2008, 02:12:14 PM: Man up and take the pain.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Madrun Badrun on July 24, 2008, 02:12:21 PM: Jesus. Just go around with a butt plug all day and concentrate on that instead of the pain.

spoiler (click to show/hide)
and take pics.
[close]
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:12:25 PM: Quote from: FlameOfCallandor on July 24, 2008, 02:09:40 PM
Be sure to tell us the magic amount after you find out.

Well, I won't be able to make it to a computer when I'm DEAD, but I'm sure there will be some pre-death warning signs. I will report back with how much I took before I started peeing blood.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Eric P on July 24, 2008, 02:12:34 PM: Adverse effects

Main article: Non-steroidal anti-inflammatory drug

Ibuprofen appears to have the lowest incidence of gastrointestinal adverse drug reactions (ADRs) of all the non-selective NSAIDs. However, this only holds true at lower doses of ibuprofen, so over-the-counter preparations of ibuprofen are generally labeled to advise a maximum daily dose of 1,200 mg.

Common adverse effects include: nausea, dyspepsia, gastrointestinal ulceration/bleeding, raised liver enzymes, diarrhea, epistaxis, headache, dizziness, unexplained rash, salt and fluid retention, and hypertension.[11]

Infrequent adverse effects include: oesophageal ulceration, heart failure, hyperkalaemia, renal impairment, confusion, bronchospasm, and rash.[11]

Very infrequent adverse effects include Stevens-Johnson syndrome.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:15:54 PM: I don't have any of those adverse effects. Except headaches, but I think that's more related to the pain. I'm also taking 2 Alleve every 12 hours.

I'm pretty sure I'm basically indestructible, but doomed to always be miserable. I'm basically a complex character from a myth, or an interesting and conflicted Shakespearean character. I'm also really funny.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:20:14 PM: Quote from: Genghis Cohen on July 24, 2008, 02:17:36 PM
o how culture has fallen when some guy can be considered for the pantheon for being able to endure slightly large doses of over the counter painkillers.

Well, it makes sense. Dyack is todays equivalent of Shakespeare, and Muse is today's Michelangelo, and Nolan is todays, I dunno, Antonioni, so standards have fallen across the board. I blame the weak US dollar.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Bocsius on July 24, 2008, 02:26:07 PM: Quote from: TVC 15 on July 24, 2008, 02:20:14 PM
Well, it makes sense. Dyack is todays equivalent of Shakespeare, and Muse is today's Michelangelo, and Nolan is todays, I dunno, Antonioni, so standards have fallen across the board. I blame the weak US dollar.

Which can only be blamed on Canadian infiltration.

As always, the blame lies with Canada.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Howard Alan Treesong on July 24, 2008, 02:27:32 PM: do you want me to send you my leftover vicodin, Dr. House

unfortunately I am out of my Japanese butt pills, that stuff was the business
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:30:05 PM: Quote from: Synthesizer Patel on July 24, 2008, 02:27:32 PM
unfortunately I am out of my Japanese butt pills, that stuff was the business

Oh my sweet Jesus.

Oh, I also neglected to mention that the only way I can sleep is through the magic of alcohol. Specifically, Hurricane. I was trying to describe Carlo Rossi wine to Patel the other night, and I said it's like cheap grape juice mixed with Hurricane. Later that night, at the 7-11, looking for booze to put me to sleep and numb the pain, I saw Hurricane and figured it must be fate.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: duckman2000 on July 24, 2008, 02:33:49 PM: Following surgery, I'd take 6x600mg tablets a day, which was the maximum according to the doc. But then I also ate a royal shit ton of oxycodone and hydrocodone.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: drew on July 24, 2008, 02:35:54 PM: Taking that much advil everyday will fuck up your stomach. Go to the doctor and try to get some vicodin.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Howard Alan Treesong on July 24, 2008, 02:37:15 PM: Quote from: TVC 15 on July 24, 2008, 02:30:05 PM
Quote from: Synthesizer Patel on July 24, 2008, 02:27:32 PM
unfortunately I am out of my Japanese butt pills, that stuff was the business

Oh my sweet Jesus.

Oh, I also neglected to mention that the only way I can sleep is through the magic of alcohol. Specifically, Hurricane. I was trying to describe Carlo Rossi wine to Patel the other night, and I said it's like cheap grape juice mixed with Hurricane. Later that night, at the 7-11, looking for booze to put me to sleep and numb the pain, I saw Hurricane and figured it must be fate.

They were incredibly powerful suppositories and you had to keep them in the freezer. :-[

They also knocked me the fuck out.

Don't take that much ibuprofen, it is very physically dangerous.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: MrAngryFace on July 24, 2008, 02:41:17 PM: Hospitals will dose as much as 3200 mg.

Let me repeat:

HOSPITALS will

not you...
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:44:11 PM: I'm only taking 1600-2000 at a time. When I said 4800 to 6000, that's per day, total.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: duckman2000 on July 24, 2008, 02:45:05 PM: Quote from: TVC 15 on July 24, 2008, 02:44:11 PM
I'm only taking 1600-2000 at a time. When I said 4800 to 6000, that's per day, total.

That's quite a lot.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: demi on July 24, 2008, 02:45:23 PM: You should just down the whole bottle and save us the sob story. You're worse than PD.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Bocsius on July 24, 2008, 02:46:09 PM: Here lies White Man.

He was 37.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:46:15 PM: Philip K. Jung. This is clearly the dentist meant for me.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: MrAngryFace on July 24, 2008, 02:46:47 PM: Yeah you need to see a doctor about you know, real pain killers. Youre gonna mess up your stomach
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:50:01 PM: Oh, I was toilet tantruming way way way before this.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Positive Touch on July 24, 2008, 02:56:02 PM: fucking weak. even when my back pain is at its most insane i only take 1600-2000 a day. just suck up the rest of the pain or go see a doctor for fuck's sake.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 02:56:54 PM: Quote from: Positive Touch on July 24, 2008, 02:56:02 PM
fucking weak. even when my back pain is at its most insane i only take 1600-2000 a day. just suck up the rest of the pain or go see a doctor for fuck's sake.

I'm looking for one now, fret not.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Human Snorenado on July 24, 2008, 04:26:18 PM: Is this related to your shitty teeth? Or is it some sort inner, emotional pain? Because if it's the latter you should just smoke dope or something. Honestly, you should probably be doing that anyhow.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: Smooth Groove on July 24, 2008, 04:32:28 PM: Why won't you go get some antibiotics like I told you to?

Luckily for you, overdosing on Ibuprofen doesn't seem to have too many life threatening effects although you should definitely cut down on it. If Ibuprofen's not stopping the pain, then taking more won't help.

DOSING: ADULTS
Inflammatory disease: Oral: 400-800 mg/dose 3-4 times/day (maximum: 3.2 g/day)

Analgesia/pain/fever/dysmenorrhea: Oral: 200-400 mg/dose every 4-6 hours (maximum daily dose: 1.2 g, unless directed by physician)

OTC labeling (analgesic, antipyretic): Oral: 200 mg every 4-6 hours as needed (maximum: 1200 mg/24 hours)

Overdosage effects:

LINICAL ASPECTS OF ACUTE TOXICITY

General — Acute toxic ingestion of NSAIDs often present to emergency departments and represent a sizable percentage of cases reported to regional poison centers [1] . The clinical manifestations of acute NSAID overdose tend to be minimal. In a review of over 5000 NSAID overdoses, the most common signs and symptoms were nausea, vomiting, drowsiness, blurred vision, and dizziness [8] . Less than 0.5 percent of these patients experienced severe harm (eg, renal failure); most required no medical intervention. In general, ingestions of less than 100 mg/kg of most NSAIDs (except mefenamic acid and phenylbutazone) are unlikely to cause any significant toxicity. Massive ingestions with severe symptomology are seen with ingestions greater than 400 mg/kg [9] .

Acid base abnormalities — An increased anion gap metabolic acidosis may be seen after large ingestions of NSAIDs, particularly ibuprofen, naproxen, and phenylbutazone (a veterinary NSAID occasionally ingested by humans). This acidosis may represent a combination of lactic acidosis (from cellular hypoxia or seizures) and weakly acidic NSAID metabolites.

Renal insufficiency and renal failure — Acute forms of renal failure and renal papillary necrosis are rare in NSAID overdose. Most commonly, these pathologic processes occur in patients with decreased effective arterial volume (congestive heart failure, cirrhosis, protracted dehydration), age-related underlying renal dysfunction, or massive overdose.

Patients with NSAID-induced acute renal failure usually present with evidence of decreasing renal function (increased BUN, increased creatinine, hyperkalemia, decreased urine volume, or weight gain).

The diagnosis of acute renal papillary necrosis may be more difficult. Patients classically present with gross hematuria and renal colic, secondary to ureteral passage of sluffed ischemic renal tissue. Often the clinician must inquire specifically about a recent large ingestion of NSAIDs to confirm the diagnosis. (See "Manifestations and diagnosis of analgesic nephropathy").

NSAID-induced renal injury likely results from inhibition of vasodilatory prostaglandins. Prostaglandins preferentially dilate efferent arterioles in the glomerulus, helping to maintain renal perfusion; prostaglandin inhibition shifts the balance towards vasoconstriction and decreased perfusion. Discontinuation of NSAID use has been shown to reverse the renal insult in most cases [10-14] .

Central nervous system toxicity — Acute central nervous system toxicity related to NSAID use is pervasive and varied. A prospective study looking at ibuprofen overdose noted that 30 percent of patients experienced CNS effects ranging from drowsiness to coma [7] . Case reports have identified numerous neurologic sequelae including ataxia, nystagmus, headaches, and disorientation [15] .

Seizures have been reported with ingestions of propionic acids (ibuprofen), pyrazolones (phenylbutazone), acetic acids (diclofenac and indomethacin), and anthranilic acids (mefenamic acid and meclofenamate) [16-21] . Most cases occurred after large ingestions, but even small therapeutic doses have been associated with seizures in certain patients. The mechanism by which NSAIDs cause seizures is not clear. Some speculate that decreased cerebral prostaglandin and thromboxane synthesis may lower the seizure threshold [19,21] . Seizures are effectively treated with benzodiazepines.

Hematological toxicity — Aplastic anemia and agranulocytosis have been associated with the use of phenylbutazone and indomethacin [22,23] . In one case of aplastic anemia, the patient presented with bleeding gums and a diffuse petechial rash after ingestion of an herbal supplement containing phenylbutazone [23] . Phenylbutazones were removed from US markets in the 1970s, but they are still available in veterinary formulations and in other countries. Discontinuation of the drug has been shown to reverse the hematologic disturbances.

Allergic reactions — NSAIDs may cause anaphylactic and anaphylactoid reactions, particularly in patients with chronic urticaria or asthma [24] . This is due in large part to cyclooxygenase-1 (COX-1) inhibition and resultant overproduction of leukotrienes [25,26] (show figure 1). Patients may present with any degree of severity, from mild urticaria and rash to hypotension and cardiac arrest. Standard treatment for anaphylaxis is effective. (See "Anaphylaxis: Rapid recognition and treatment", section on Management). All patients with NSAID or aspirin-related allergies should discontinue all nonsteroidal medications, due to unknown rates of cross reactivity.

The safety of COX-2 inhibitors in patients with known NSAID allergies is unclear. Four reported cases of adverse reactions to celecoxib suggestive of anaphylactic shock have been reported [27] . Due to the paucity of data regarding safety, current recommendations are that patients with known NSAID allergies should refrain from using COX-2 inhibitors.
Title: Re: So, how much ibuprofen can I consume before I die?
Post by: TVC15 on July 24, 2008, 05:16:58 PM: I got an appointment for tomorrow, so if all goes well, this will be the end of the TVC15 Death March, sponsored by Ibuprofen, Alleve, and Hurricane Malt Liquor.