I've basically cut ties with everybody in my life and lived like a hermit with most of my social interactions being online. I'm not necessarily happy, but can't say I'm sad either.
Once you've been in the void long enough, you get used to it 
This is me now, in a way- aside from work and family, that's about it for my socialization. Most of my friends have either moved away or just become unavailable because of kids and stuff. I don't even play stuff online with people anymore since nobody is ever online or playing the same stuff these days. Hell, I barely even play games with anyone on my friends list, let alone with IRL friends. And it was almost funny how I came back to the States and then several friends who had moved back here returned to Japan almost immediately after.
I did cut ties with one friend, but I don't think he even realizes it- the guy stopped hanging out with me after he met his girlfriend years ago, and I've seen him three times since then- once when he started dating her, at their engagement party, and then at their wedding. I hear that his wife is incredibly controlling, but the reason I stopped talking to him was because he promised he'd come help me with something one weekend and no-showed twice, not even bothering to say anything the second time. I gave up trying to hang out after that. That was three years ago.
Also from time to time, I get kind of depressed living here and wish I was back in Japan. I really enjoyed living abroad and would like to go back. The problem is that I don't know what the hell I'd be able to do, since I don't want to do the English thing again and my Japanese skills are even worse now than they were before. Moving to another city might also help. I really don't think I like Atlanta but it is nice having family close by. Sometimes I think it was a mistake to move back to the U.S. at all, but coming back here helped me to start a career and now I've got a good job, am a homeowner, and all that stuff. I doubt I'd be making as much money abroad and probably wouldn't have been able to afford a home and two cars.
Part of the problem, besides my general shyness, is that I think I have some anxiety issues that I've never been treated for. I also tend to be very much a shut-in and being cooped up doesn't help things. Yesterday when my wife came home from work, we went for a walk and I felt 100 times better. I need to get my ass out and start doing things again.