The Circle Pad Pro definitely helped. Made holding the 3DS a hell of a lot more comfortable and let me circle-strafe in a few situations.
I just beat the game and it was overall pretty damn enjoyable. There were one or two spots that frustrated me a bit (cheap deaths), but I just turned the system off for a bit, came back, and beat those sections.
I can't say much about the game without spoiling stuff, but one thing that's NOT a spoiler is that this game is a prequel to Resident Evil 5 and leads into in nicely, and I also assume that part of the ending ties into Resident Evil 6.
This game ended up being REALLY story-heavy, but still had enough action to balance things out. I don't think it's as replayable as RE4 and RE5, but with Raid Mode there's not much of a reason to replay the campaign anyway, unless you're trying to unlock all of the mission-achievements.
I barely used 3D in this game, too. Weird since I thought it worked really well in The Mercenaries 3D.
Story/game play spoilers for those who don't care:
spoiler (click to show/hide)
-During the boss battle on Episode 11, you're given four rocket launchers. If you're quick enough and have enough ammo for your other weapons, you can keep one of the rocket launchers and use it on the game's final boss. I read it's a one hit kill. :o
-All of the main characters survive in the end.
-Keith goes to the African branch of the BSAA. Is this is the same Keith who ends up biting in a helicopter in RE5 Desperate Escape?
-Footage of the very beginning of RE5 Lost In Nightmares is shown, with the epilogue saying that this is Jill and Chris's next mission.
-Parker meets up with Jessica in a scene after the credits and gives her a surviving T-Abyss virus vial. I assume this is something for RE6?