i used to mess around with a nurse who wore bi-weeklies but wore them for like a month or so. At least she put drops in before bed and in the morning. The only time i sleep in mine is when i'm at some chick's house and we have sex and i just don't feel like taking them out afterwards, or i don't have a spare case. After the nightmarish experience i had a little over a year ago, i fear for my vision every time i doze off with my contacts in.
i just got over an eye infection that lasted a month. i ended up reinfecting myself somehow in the same eye. The cause was totally my fault -- i was wearing my two-week contacts for two months (taking them out at night) while i ordered some extras. i tried not to, but my allergies were really bugging the hell out of me and i did rub my eyes a lot, which combined with old contacts probably caused the infections. My ophthalmologist also recommended using eye drops (Optive is the new hotness) and blinking more because my eyes were really dry (computer use, dry air conditioned air). Even now that the infection's gone, my right eye is still a little itchy. The Optive helps a lot with that.