Well, Buffalo at its height (the 1950's) had over 600,000 living in the city limits, when I lived there the population was about 290,000 and now I think it's down to 280,000... about 90% of the people I went to college with, who were from the metro area, left for greener pastures, a lot of them went to DC, some to Seattle, a couple to LI/NYC and CT... Outside of the university and small pockets here and there, there are hardly any jobs remaining. Many of the factories closed down and remain on the waterfront, abandoned and rotting. Combined with the constant grey skies in the winter and the famed snowfalls, it's one of the most depressing places I've ever been to. Some of the suburbs are very nice though if you can get past the weather (the university was in Amherst, one of the safest cities in the US and very comparable to the part of Long Island I'm from).
Quite a number of these abandoned houses mentioned are crack houses, especially on the East Side... in fact there are whole streets with abandoned houses there. The Buffalo metro has some of the lowest housing costs in the country, too. It's funny I could probably buy a house on the East Side with slightly more than I paid for my car, but why in god's name would I want to???