girls - i am saying nothing about this series for fear of giving you any sort of preconceptions. just go and get it
I finally disagree with you on something! (Well, besides Finder, I guess.) I found Girls to be kind of obvious and ultimately pointless. Also rather clumsily drawn.
Anyway, to round out the rest of my filthy indie picks now that I'm at home... um... actually, I covered pretty much everything I wanted to except for Gene Yang's awesome
American-Born Chinese.
For mainstream stuff, I'll second Eric P's recommendation of
Immortal Iron Fist and add
Empowered, a tongue-in-cheek parody of T'n'A superheroine books;
Planetary, an awesome pastiche/investigation of popular comics in general; and
Girl Genius, which I guess is technically indie but has everything I wish mainstream superhero stuff had in it, so I say it counts. (Get the color volumes, not the B&W ones.)