my friend and I were messing around with can of air like that while brewing beer. He held it upside down and sprayed it on the back of his hand. Not to be outdone (and after calling him a pussy) I held out my hand and he started spraying. I never moved my hand and he stopped spraying because he knew it was going to be bad. Not only did skin fall off, but that part of the back of my hand has less feeling than the rest of my hand, even today a few years later.
We called the beer "Ice Burn Ale"