I like Mass Effect, but it did have bad shooting mechanics. Not as bad as Jade Empire's fighting mechanics, but still really bad.
Biggest problem with Fallout 3 shooting mechanics are that they put so many targets on the enemy for VATS, so when using manual aim, you have to be expected to have some kind of super accuracy. People buying this console will probably always be using VATS. I mean, that crab enemy was like the Death Star or some shit with having to shoot a tiny hole in the middle of it's body.