Based on the 1st 60 mins, RE5 seems quite a bit easier than RE4.
Btw, did anyone check out the RE5 benchmark tool for the PC? Based on the tool, RE5 should run awesomely on the PC like all the recent Capcom PC ports. I've got the 360 version already but I think I'll just wait to play it on the PC. The 360 version looks great for a console game but it can't come close to the PC version running at 60fps w/max settings in 1920x1200.