The best thing has been my friends seeing me watching a later episode and then being like "WHAT THE FUCK! I THOUGHT IT WAS AN ISLAND SHOW!" When people ask if they'll like it, I always tell them "You know how you can watch the first season of a show and then go to like the 4th and usually pick it up after a few episodes? It's usually just character changes and whatnot? Well with Lost, if you were to do that, you would be so damn confused it's not funny."
The first episode I ever watched was the Season 2 finale, then I watches Season 1 the next day and if it had not been for the same actors, I would have thought I was watching the wrong show.