ME3 is going to be GALACTIC WAR
Anyone you helped will join you in the ranks - tons of hints dropped. Rachni, Wrex, Quarians.... etc
Yeah, I think this is pretty much where the series is going. Patel told me in IM that it would be awesome if you could cure the genophage in the third one, leading the way for Krogans to kick ass.
I think if you fucked over certain species (Geth, Rachni, Krogan, etc.) that you will be able to defeat the Reapers by being a martyr of sorts (you won't survive), but in order to live through the campaign, you will have needed to unite all the alien races against the Reapers. So if you flushed the Rachni queen in the first one, you die.
So many people would be pissed.
