I haven't completed Mass Effect 2 yet, so I can't really comment about the story at length.
I agree with the characterization comment. But even then, it's still typical soap opera stuff. I'm not complaining, but at least in DA, helping the different races foreshadowed a greater objective.
In ME2, everyone has their own personal problem- "Oh, yo daddy went missing for 10 year and now you want me to go find him? Well I'm sure he can wait a few more days while I save the entire HUMAN RACE, guy!"