Ika Musume - Probably the closest thing we'll ever get to a Yotsuba anime. Episode 5 was another great one, Part C was :'(.
Soredemo Machi - One of my favorite Shaft/Shinbo series. See, it doesn't cram too much information and gags onto each second of screentime, it doesn't have too many characters that aren't that funny, and it's doesn't try to hard to be "artsy". Most of the series is just Arashiyama being a total idiot and Moriako slowly becoming insane because of her. Love this show.