Yeah, it's one of
those threads again.

Personally, I am anticipating:
Civilization V - Combat overhaul, fuck yeah
The Witcher 2 - Still gotta beat the first one, but the sequel looks orgasmic
Rock Band 3 - I think I'm the only person who still isn't sick of plastic instrument games and I hope Harmonix has the decency to put Black Sabbath, more Lady Gaga, and Creedence Clearwater Revival in the game.
Portal 2 - Because Valve is awesome.
Guild Wars 2 - I bought the first game off Steam and I find the MMO Lite gameplay to be quite addicting. The changes in the sequel sound pretty good.