Theories:
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- When it was announced that we're going to see the first meeting between the doctor and River, they were referring to the 200-years older Doctor meeting River on that shore (as in, she's the girl in the astronaut's suit in 69 and on the beach). So we've seen in the first episode two different Rivers as well as the two different Doctors. The only argument against this so far, is that the girl had an American accent.
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- River Song is in jail because she killed the Doctor.
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- Amy's pregnancy is a pretty big deal, a potential twist would be that she shot her own kid lol, although I've yet to see some proof giving weight to this.
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- The Silence has, as you have probably guessed, been appearing throughout season 5. The characters have seen them in more than one occasion, but clearly forgot. They're obviously what caused the Big Bang.
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- Some are suggesting that they might not be evil, but that is countered by the one killing Joy (woman in the bathroom), I can see it going both ways honestly.
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- The marked numbers on the characters' skin (as seen in the previews) is probably the number of times they've seen the Silence.
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- The ship that River and Rory investigated was the same one from "The Lodger" episode. From the few bits that we know: someone who kills Timelords appears later in the series, and that James Corden's character comes back. Not only that, but The Lodger was the episode where Amy saw a Silence in the TARDIS.
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- The regeneration shot at the beginning of the episode is different from the one that was in the teasers/trailers, meaning there might be another regeneration this season. Whether it's a different one, or the same one re-imagined after altering the timeline remains to be seen.
And that's all I know at the moment. Everything is pure speculation, none of those theories are confirmed or leaked. Also, someone spent the time to draw the Doctor and River's encounters through their opposite timelines.
