Way too early to tell and even then, who knows.
For instance, I was dead set against the Wii until Mario Galaxy came out. That is probably my game of the generation there.
That said, this upcoming generation, I will have the least amount of spare time ever in a console generation. It is hard for me to keep up and buying games just means that games will sit around for a while. Shit, I bought FFXIII-2 and Tales of Graces F and both are still in their shrink wrap. Granted, part of it is that I was still playing Warriors Orochi 3 but still, I have maybe 5-6 hours of prime gaming time a week. If work is slow, maybe double that amount. That isn't much.
Part of me is just tempted to stick with the monster $2500 PC I put together. Steam always has some awesome deal on a game I want to play and it manages to play every new release I want with max settings at full frame rates. It kind of seems like a waste for me to buy this expensive rig and then let it gather dust to play PS3.
I think this E3 will be pretty important to me in terms of what I want to do for gaming. The Wii U is going to shatter a lot of dreams Nintards have built in their head and I don't feel the slightest bit sympathetic for them. I'm sure we'll see the next PlayStation and Xbox or at least some kind of game announcements. I won't be swayed by Sony's bullshots that they are so well known for but I think you could suss out what the next generation of consoles can do.
Regarding handhelds, I have no interest. The Vita is almost flatlined and let's be honest, there is very little Sony can do to turn that around. The 3DS has a couple of titles I'm interested in but I don't really know when I'd have the time to play them. The Vita would be interesting if someone hacked into it, I think it could be a beast of a machine with the right media playback functions and emulators.
So there's my thoughts. Nobody probably cares but I think this generation is the first one I thought about sitting out. Whereas I just had to have a 360 so bad for this generation that I imported a Japanese 360 and played the games that had English text (which were quite a few in those days) and yes, I even waited in line (briefly) for a Wii + Mario Galaxy. I just don't have that enthusiasm this time around and I blame my 50-60 hour a week job plus my furthered education.