You're saying The Avengers didn't do gangbusters with women? Wanna guess how many of those tickets were sold to people who never read a comic and barely watched any superhero cartoons? RDJ, Thor's actor, etc is what drove ticket sales. How many people who saw Transformers gave a shit about the cartoon or toys?
Put it this way: if a film only appeals to Manabyte, me, EB bros, etc...it's probably going to fail.