I played, overbred my first Shelter which gave me two DO-NOTHING mouths to feed in the early game. Also forgot to recall my wasteland wanderer, so he died. Then I was short on everything and struggling to get items back above baseline, when I realized that my lack of water had rad-poisoned everyone, and I didn't have enough Rad-Away™ to recover peeps.
When I started a second Shelter, it crashed. So I deleted the first Shelter, began a new game in the first slot, and it crashed. And crashed every time I tried to load any game.
So I deleted it.
Oddly, it did make me want to go back and play Fallout 3.