I'm pretty certain, like at least 70% sure, that they actually directed way more of V for Vendetta then they were credited for. "Officially", they only did the ending fight scene, "officially", but the career of James McTeigue has been remarkably unspectacular when he's not affixed to a Wachowski production.
Also, Bound is fecking great. All three of its leads got career best parts/performances in it, and its one of the most densely and cleverly plotted noirs I can recall.
I would say that this might have been a problem for her career, but really, the back-to-back-to-back financial meltdowns of the last three Wachowski movies will be the real obstacle to them ever getting a big budget anything to make ever again. I'll always be excited to see what they come up with next, but I'm not expecting it to be anything of especially high profile in the near or perhaps even far future.