There are heaps of SF novels that run with this idea, or play with the concept that we're being shielded from interference until we're big enough to play in even the minor leagues.
But, yeah, I tend to think along Peter Watts' line of thought: even if there's no malicious intent, the alien organisms may be so out of alignment with what we consider intelligence that we may have no hope of communicating. Echopraxia was like this, to a degree. But Blindsight is a scary-as-hell story which will really get you queasy with worry.