Centrist Dems lost tonight in Tennessee, Indiana, and probably Missouri.
"Just run a campaign disassociated from the national party, geared towards local opinion" isn't a new idea. It's what 99% of candidates do in districts where they're at a severe partisan disadvantage, and it usually doesn't work... because they're at a severe partisan disadvantage.
Doesn't mean it's typically a bad strategy, but it's not setting the world on fire either.