I mean, like I say, YMMV, but Bloodlines doesn't really give throw you much of a bone in terms of 'Paragon' choices, and ultimately the 'good' options you have open are 'unwitting pawn' rather than any kind of heroism.
Yes. My point is, the same is true for games with an organized crime theme or a post-apocalyptic setting. Loss of humanity is implicit, but unless you're confronted with it it's not a strong theme, because in video games, combat/violence is an important pillar. (Which is why the "Nathan Drake's a mass murderer" and "Gordon Freeman is a mute psychopath" takes are mostly only good for jokes.)
I haven't played Vampyr, but from everything I've seen, that game's story revolves around your struggle to stay human. VtmB is, as you say, a power struggle where you're playing the unwitting pawn in other people's schemes and that also happens to be set in the World of Darkness universe.
From that perspective, I'm not worried in the least, because it's gonna be a video game.
The sequel might lean into it more, for all we know. A recurring human character who reacts to your choices would be good. Imagine if Grünfeld Bach were more than a caricature of a zealous hunter and acknowledged your attempt to stay human.
