Never done anything harder than pot, and that happened once to my normal knowledge, twice if you count it happening while I was drunk off my ass. I would, possibly, try mushrooms at some point, maybe.
As for anything else? No, thanks. I'd rather spend my money on more productive things and stay out of jail and stuff. Hard drugs are the suck and I don't really tend to associate with people who do them.
I do have a friend who used to be big into heroin, and is on methadone now and has pretty much completely cleaned himself up. We share similar hobbies and spent a lot of time together, but even if I were single/in an unhappy relationship I would never date him, just based on his past. Maybe that makes me a mean and/or shallow person, but that's just how I feel.