Most American animation, outside of some movies [Pixar, Disney, sometimes Dreamworks] and stuff like Adult Swim, doesn't really interest me that much. I think part of that is that most just don't really have a cohesive storyline, just lots of standalone episodes and maybe sometimes they'll mention something bigger going on.
It's not an East vs. West thing either, because I don't really like super-long animes either [One Piece, Naruto, Bleach, DBZ, et al].