I just read Shaq's autobiography - ok, Martin Amis he is not but every single team he's ever been on is fascinating - and it turns out most of his injuries, including the one that ended his career, stemmed from one arthritic toe. The impact of that rippled up throughout his body, causing all kinds of problems. The reason for his sudden resurgence in Phoenix was pretty much that the Suns' trainers figured this out and were able to fix most of it. The big issue was that his glutes weren't firing properly, which is something all of us cubicle slaves and gamers need to consider. When muscles that big stop working, a lot of other smaller muscles end up picking up the slack, and of course they aren't big enough. So you always got to be prehabbin' that stuff. Lots of good stuff in Ferriss' 4 Hr Body on how to do that, some of which i've been experimenting with recently. Mostly though, kettlebells get the job done - turkish get-ups and swings are a very common prescription for fixing all these imbalance-related injuries.
