How did it change anime then? Before Akira, anime received most of its revenue from films and toys. The same thing continued after Akira. Evangelion popularized the television format, which created a televised anime boom after it started getting popular and being heralded as the greatest anime tv series of all time. That's without bringing up the pseudo intellectualism Eva brought to the table that became so prominent after its release.
Did Akira help create more mature works of films being created? No, it did not. Golgo 13 is probably far more, if not equally bloody than Akira ever will be and just as controversial in regards to sex. The Professional predates Akira by
five years. Even Grave of the Fireflies was released before Akira. How did Akira change anime? It didn't.
Did Akira help create a wave of more cyber punk anime? Sure. But how is that directly attributed to Akira when cyber punk was big during that period to begin with?
Akira is a highly influential anime. However, it didn't change the industry -- literally -- on its head like Evangelion.
Akira probably changed anime for overseas masses by exposing them to anime, but it didn't really
change anime. Akira's influence is mostly seen through how it influenced
manga, particularly the art, and that's mostly because of this:
Not this: