I think Wilson will be fine; he's a pretty cool customer for the most part. His biggest problem is that his weapons are dogshit, and I don't care what anyone says, Percy Harvin isn't going to be a factor. All the Broncos have to do is bump him within the five yards and he'll break on the first play.
As long as Lynch can keep running the ball and getting yards after initial contact, I think Seattle should be favored. If Seattle can put up 20+ points, that will be enough to beat Manning with their defense. If they can't, they won't. Hopefully somehow Peyton Manning suffers a career ending injury on a touchdown pass that emasculates Richard Sherman somehow... not sure exactly how that works but I can dream.