I agree with that Lager, it's his main outlet of expression and he didn't consider how much it radically differed from what was expected from CAD*. I find the meme funny because of how it unintentionally changes the entire mood/tone of the strips when you replace the last panel with it no matter what proceeds it. In many cases they often make them far funnier if you like dark humor. Especially when you have one of those over-explaining the mundane joke strips and it suddenly swerves into horribly dark territory. In this case where instead of a silly sexual thing with Gabe, the potentially horrible ramifications of the technology are an event that's twice as negative for Buckley personally. And I think there's often more of a subtly from it when used as a final panel which here leaves the horrible way the technology works to the imagination instead of showing it directly. (Which is often a criticism of Buckley's work and why I think the panel is regularly so effective as a replacement.)
For the record, I think there are far far funnier things than miscarriages. Like say, genocides.
*And I don't recall if he's ever admitted it was "clumsy and inappropriate" as Oscar puts it, which is why some people take pleasure in it. In my case I like the juxtaposition that the final panel change brings. And I'm an unabashed fan of dark, dark humor.
