My biggest issue with the game (aside from UI and some of the graphics) was the way NPC's were handled. You couldn't manipulate their inventory and they often did dumb shit. You could even get trapped by them in corners and have to reload from a previous save.
Later in the game, their help is neglible, but early on when one missed shot often meant the difference between life or death, it was infuriating.
It was better in FO2, but the story wasn't as good.