I don't know. Some people are very visual in that, its awkward to see a person on screen mirroring your position. Its not disconcerting to most but you can't rule out that there are people that do get thrown off by it (and is an issue)
It could be that Dragona is just bitching but who knows what the case actually is.
Its already been stated but, if it wasn't an issue at all, why would Nintendo change up link in the first place? Why couldn't he just say left handed and use righties play it that way? As already been said, Nintendo's play testers said they were having issues with the game due to link being Lefty so Nintendo went out of there way to mirror the game world. That says something about the Right Handed/Left Handed issues.
These play testers were obviously having the same issue Dragona is. Also, since Righties never have to use their Left hand for anything really mechanical (as far as writing and stuff) you would think this issue would be more apparent. Lefties do adapt and become ambidextrous so that can also be why there are so many Lefties that are cool with it. But what about the ones that very Left handed dominant?
Theres obviously some people out there that are affected by this and its not because their distinguished mentally-challenged (lawl)