I was playing this last night, after having a bit of frustration I actually managed to level up a bit, and do a few quests... met up with Three Dog and now I have to find the

Lunar Lander

(the game gets points in my book for featuring that!), did the quest with the vampires in the metro station, disarmed the bomb and got my own house. Also found another vault filled with insane survivors, and a bobblehead there. Now I'm saving up for my own infirmary.
Some comments and questions:
-I kinda cheated a bit and looked at a FAQ online, noticed there were only something like 30 quests (and I assume, 1 achievement per quest)... will probably do these, get the bobblehead achievement, and the 100 areas achievement. Can you get all the quests on the first run through the game, I know obviously you won't be able to get the level 8/14/20 good/neutral/evil achievements all on one run. I'm playing it pretty straight so far, though I'll occasionally loot and try my hand at hacking.
-What are some of the best combat strategies? I'm working on building up melee and small guns (I like the Assault Rifle so far). What I do is I'll go into VATS mode, get off a few hits, then just constantly shoot at them/melee at them and run away while my AP recharges, where I go into VATS again.
-How the hell does lockpicking work?
-If you fail in hacking a terminal, picking the lock on a box, or picking the lock on a door, are you ever able to retry or are you fucked for good?
-I'm on level 5, about to hit level 6. What are some recommended perks and skill distributions? I assume you should minmax and specialize, not try to make a general character.
-Not a fan of the dungeons, the localmap is confusing as hell, and everything in the dungeons tends to look the same, which makes navigation annoying.
-Drewsy: I had the game crash on me once so far during a loading screen. But I think my 360 drive sucks and this has happened on a number of other games. I have to fix the leaking pipes around Megaton as well.
Overall, I'm starting to get into this game, and I definitely like it MUCH more than Bioware's stuff.