I agree with most of Oscar's post except consoles going away. I do think that it might be time for one of the big three to bow out, but I think there will always be a market for dedicated gaming hardware (that also sort of acts like a DRM machine.)
I also think it's time for Nintendo to go third party.
It could be Nintendo or it could be Sony. I doubt it will be MS as the 360 is quickly becoming one of their most important, successful areas and will only continue to get more important in the future as the home media space from Google and Apple heat the space up.
Sony is hemorrhaging money hand-over-fist, the Vita is a bomb and I hear they're going batshit crazy with the PS4's specs which would be great except for the fact the PS3 sucked up all their PS1/PS2 moneys like a black hole and they have nothing in reserve to cushion the fall. And honestly, a "success" like the PS3 has had might even be too optimistic for PS4.
Nintendo's vulnerable because they only do games, but like Disney their IPs will always be worth something and they have a pretty large amount of cash in reserve from what I remember. They'll at least survive this upcoming generation and if they don't completely bomb out Vita-style I think they should be OK. I think retail-digital games for 3DS and on launch for Wii U shows they can at least change quickly enough
when they decide to (if the 3DS's adequate online didn't show otherwise -- adequate being a step up from fricking untenable.) The eShop's actually pretty good but not nearly at Android/iOS levels yet obviously, but then again none of the others are except maybe XBLA.
Sony and Nintendo really need to make a quick-entry, digital-only, route for indie devs. The ESRB/PEGI/etc. requirements alone pretty much kill any indie interest in their platforms (if the $2,650 devkits and license fees, not to mention the office requirement, didn't do that already.)