I think the Dem agenda relies more on passing a bunch of stuff than the GOP agenda.
Potential Dem legislation: health insurance (public option, drug prices, etc.), family leave, pre-K, student loans, voting access, campaign finance, taxes, bankruptcy, labor, immigration, housing, qualified immunity, gun control. Even if the Senate Parliamentarian gives you a ton of leeway on reconciliation, that still gets you one bite at the apple each year.
The GOP wants to lower taxes on rich people and corporations and pack the courts. So far they've gotten cold feet on privatizing SS, Medicare, Medicaid, etc. It's possible without a filibuster that eventually they pass some shitty stuff on labor, abortion, immigration, law enforcement. ALEC's gotten a lot of stuff through state legislatures so it's not out of the question. But Dubya got bills through by tacking to the center and Trump's produced almost nothing. On balance the Dems should nuke the filibuster and take their chances.