So Smiley was a Smile and after dying, his devil essence went back into that devil fruit for future testing/sale. Badass.
So maybe the Devil Fruits rule I came up with a few pages back only applies to artficial devil fruits? I think not. I bet that with the knowledge that Blackbeard is off collecting DFs that Doflamingo and co are trying to beat them. A Devi Fruit arms race so to speak. Pekums is probably the first of the artificial devil fruit users we've met. I'm sure Big Mom's entire crew are made up of Zoans.

Along with this, imagine Law's part in this. He has a crewmate that is a talking bear. Is Bepo a Smile user? Is that why Law's jolly roger is similar to Doflamingo's?