I suppose there's scope for it to be funny if they lampoon woke people, q distinguisheds and the overall nonsense of the modern day world, but then you run the risk of upsetting the soyboy betacucks in the games media and there being an agenda against your game
I dunno, that type off satire is already stale in a way, because it's all you find on the internet, alt-right v woke, essentially.
Maybe why SR2 was the funniest, it had the "dumbest", less snarky kind of humor, and it felt more genuine, it straddled the line between serious and dumb well enough to make you think they were serious about it, which is the only way to be funny with that kind of material.
In other words, The Room is funny because it's trying to be serious, a The Room 2 where they embrace its mockery/legacy would be a piece of shit.
But Saint's Row never had biting commentary, it was toilet humor and references anyway.