There are 3 missable achievements-
* At the very beginning where you have to save the guards and the thug in the detox room, save them all (the guards first)
* When fighting a Titan & thugs, ride the Titan and knock down 10 thugs (easy to do, once you get on the titan)
* At the very end, beat up the thugs in the hallway (no spoilers but you'll know)