The one thing for me that will be interesting is whether or not they'll get much 3rd party support this time. Yeah, I saw that list of devs, I'm sure everyone will get their feet wet. What I want to know is will there be another rush to make Wii U software if the launch goes well, regardless of the games applicableness to the hardware.
Nintendo has had a lot of luck post-gamecube deciding that the easiest way to win the race is to be the only one running in it. They're not playing catch-up with MS and Sony. Nintendo is not even making consoles which can easily deal with the INPUT from those other games' controllers, let alone the graphics/processing needs. They're making consoles which can really only run games designed completely for them... or, I suppose, games from 3 or 4 generations ago, if we want to look at the ability to run NES/SNES stuff with the default controller.
However, anyone else trying to make games usually starts from a cross-platform mistake and fails, or they make a crap game based on a very conservative ROI. Meanwhile, Nintendo first party stuff continues to sail on, on waves of scrilla.