OG RE4 has a lot of tension rather than horror for its gameplay and tone. I'm expecting that aspect to remain intact. RE4's gameplay shines due to crowd control and utilizing all your weapons to perfect crowd control.
I'm expecting enemies in REmake 4 to be very agile and utilize a lot of tools and crude weaponry, at the cost of not being spongy/being very vulnerable to being stunned by player weapons.
Villagers luring you into traps, purposefully pushing you into a corner or drawing your attention, less linear pathing so they can potentially stalk you or slowly follow you as you're progressing thru an area.
There's a lot that can be altered or changed that would add to RE4 as a game.