There are a ton of weird builds possible, the problem is that they mostly suck.
IMO, during endgame the problem is more with the gear than anything else. By then the only things that matter are main stat, vit, crit chance, crit dmg and attack speed. Just stack that.
Please keep in mind though that basically everything you named as a positive in D2 didn't exist until LoD, though.
For everyone who likes non-instanced loot and limited respec, play Path of Exile!